K C et al.,  Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters

Molecular Cell 2024

Birds can be highly selective during perching behavior, taking several factors like branch structure and stability, environment, and social patterns into account. In this issue of Molecular Cell, K C et al. present evidence of RNA polymerase III activity at protein-coding genes. Here, a blue bird (RNA polymerase III) unexpectedly perches on a branch conventionally selected by yellow birds (protein-coding genes; RNA polymerase II), a reciprocal pattern to previous observations of yellow birds at blue bird branches (small noncoding RNA genes, such as tRNAs).